Final diagnosis of TTP was made in 62.5% of the patients but notably, the performance of PLASMIC score in our patient population was inferior compared to prior validation studies. Of those who underwent PLEX in the setting of TMA for the concern of TTP, only about a third were started on PLEX within 24 hours.Ĭonclusion:Among our study population, only about a third were started on PLEX within 24 hours which is concerning and highlights the need for quality improvement initiatives to increase provider awareness and decrease time to PLEX.

The sensitivity, specificity and positive predictive value of PLASMIC score for prediction of final diagnosis of TTP was calculated for all patients who met inclusion criteria and is shown in the attached table.

Among non-TTP TMA, 25% had a score of >5 and 62.5% had a score ≥5. We excluded patients 5 and 70.83% had a score ≥5 at the time of presentation. Patients were identified from blood bank records and data was collected by review of electronic medical record. Methods: This is a single center observational study including patients who underwent PLEX for a diagnosis of TMA, due to concern for TTP between January 2009 and May 2019 at an inner-city safety net hospital. We aim to report the management and outcomes of TMA along with the predictive value of the PLASMIC score in our patient population, over a 10-year period in an inner-city safety net hospital. Due to this, treatment with PLEX is often initiated empirically before diagnostic test results are available. A high index of suspicion is recommended for thrombotic thrombocytopenic purpura (TTP) due to the time sensitive nature of treatment initiation and poor outcomes associated with delay in treatment. Some of the etiologies are associated with high morbidity and mortality, but there are very subtle differences in presentation. Introduction: There are multiple mechanisms of occurrence of TMA.

Plex treatment